Table of Contents

I. Background

A. Language and Definitions

1. Neurogenesis
2. Neuronal vs. Neural
3. Neural Stem Cells (NSCs) vs. Neural Progenitor Cells (NPCs)

B. Brief History

C. Overview of Neural Stem and Progenitor Cell Regulation

1. In vitro Regulation
2. In vivo Regulation

D. Product Background

II. Applications

A. Basic Research

1. Developmental Biology
2. Adult Biology

B. Drug Discovery Applications

C. Drug Delivery Applications

D. Neural Toxicology Assessment

E. Neural Transplantation

F. Brain Tumor Research

III. Application Priorities

A. Overall

1. Cell-Based Therapies
2. Standardized Neural Toxicology Assays

B. Breakdown of Neural Stem Cell Research by Disorder

C. By Segment

1. Academic
2. Biotech
3. Pharma

IV. Patents

A. Key U.S. Neuronal Stem and Progenitor Cell Patents
B. Additional U.S. Patents
C. Additional European Patents

V. Projected 5-Year Market Growth

A. Scientific Publication Analysis

1. Neural vs. Neuronal Products
2. Stem vs. Progenitor Cell Products
3. Five-Year Growth Projections
4. Conclusions from Data

B. Grant Rate Analysis

1. Neural vs. Neuronal Products
2. Stem vs. Progenitor Cell Products
3. Five-Year Growth Projections
4. Conclusions from Data

C. Patent Rate Analysis

1. Neural vs. Neuronal Products
2. Stem vs. Progenitor Cell Products
3. Five-Year Growth Projections
4. Conclusions from Data

VI. Competitors: Suppliers of Neural Stem & Progenitor Cell Products, Including Products Offered

A. Millipore, Inc.
B. Stem Cell Technologies
C. AlphaGenix, Inc.
D. R&D Systems
E. Cell Applications
F. SA Biosciences
G. ScienCell
H. Neuromics
I. Amaxa
J. Invitrogen
K. Sigma Aldrich
L. Orion (no longer in existence)

VII. Specialty Pharmaceutical Companies: Neural Stem & Progenitor Cell Therapies

A. Neuralstem, Inc
B. NeuroNova AB
C. NeuroGeneration

VIII. Breakdown of Stem Cell Research Activity by Cell Type

IX. Potential End-Users of Neural Stem Cell Products

A. Academic Labs
B. Private Labs
C. Commercial Labs
D. Government Labs

X. Product Ideas & Suggestions

A. Product Categories

1. Cells & Tissue

a. Fetal-Derived Neural Stem Cells

b. Adult-Derived Neural Stem Cells

c. Fetal-Derived Immortalized Neural Stem Cells

d. Cryopreserved Embryonic Neurospheres

e. Embryonic Stem Cell Derived Neural Progenitors

f. Embryonic Primary Neuronal Tissue

g. NSC Differentiated Progeny Cells

2. Kits

a. Kits for Analysis of NSC Differentiated Progeny

b. Stem Cell Functional Kits

c. Neuronal Stem Cell Phenotyping Kits

d. Neural Stem Cell Expansion Kits

e. Neural Stem Cell Differentiation Kits

f. Neural Stem Cell Blotting Kits

3. Media: Maintenance, Differentiation, Expansion, & Freezing Medium

4. Growth Factors

5. Markets: Markers for Neural Stem Cells & Differentiated Progeny

6. PCR Arrays

7. Nucleofection Tools

8. Neural Toxicity Assessment

B. Product Suggestions

1. Neural Toxicity Assessment Products (an untapped niche)

2. Species-Specific Opportunities

3. Areas of Underdeveloped Competition

4. NSC Derived from Novel Sources

5. Neural Rosette Cells (R-NSCs)

XI. Conclusions

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