TABLE OF CONTENTS

II. Background: Types of Stem Cells

A. Human Embryonic Stem Cells (hESCs)

1. Early, 5-7 days (totipotent)
2. Gonadal Ridge, 6 months (multipotent)

B. Fetal Stem Cells (pluripotent)

C. Umbilical Cord Stem Cells (multipotent)

1. Cord Blood
2. Cord Matrix / “Wharton’s Jelly”

D. Dental Stem Cells (multipotent)

E. Adult Stem Cells (multipotent)

1. Hematopoietic Stem Cells
2. Mesenchymal Stem Cells
3. Neuronal Stem Cells

F. Cancer Stem Cells (multipotent)

G. Induced Pluripotent Stem Cells (iPSCs)

H. Novel Stem Cell Types

1. Neural Rosette Cells (R-NSCs)
2. Very Small Embryonic Like (VSEL) Stem Cells

III. Stem Cell Research Applications

A. Regenerative medicine (“Cell-Based Therapies”)

1. Diabetes Mellitus
2. Cardiovascular Disease
3. Neurological Disease
4. Autoimmune Disease
5. Hematopoietic Disease and Transplantation Research
6. Orthopedic Repair
7. Cancer Research
8. Birth Defect Research

B. Non-Cell Based Applications

1. Assays to Aid Early Stage Discovery
2. Improved Prediction of Human Responses
3. Drug Development with Humanized Mouse Models
4. Genetically-Engineered Stem Cell Lines for Screening
5. Pluripotent Stem Cell Lines for Target Validation and Drug Screening

C. Birth Defect Research

IV. Key Market Competitors: Providers of Diverse Stem Cell Product Lines

A. Invitrogen Corporation

1. Stem Cell Products

a. Isolation and Characterization Products
b. Expansion and Differentiation Products

2. Collaborations

a. Invitrogen and Cellartis AB
b. Invitrogen and Novocell
c. Invitrogen and the Buck Institute

B. BD Biosciences

1. Stem Cell Products

a. Isolation
b. Culturing
c. Analysis

2. Collaborations: BD Biosciences and Stem Cell Technologies

C. Comparison of Stem Cell Publication Rates: Invitrogen vs. BD Biosciences

V. Product Areas

A. Primary Antibodies
B. Bead-based Cell Separations Systems
C. Fluorescent-based Labeling and Detection
D. Protein Purification & Analysis Tools

1. Protein Purification
2. Stem Cell Protein Analysis
3. Quantitative Proteomics

E. DNA/RNA Based Characterization

1. Tools for DNA & RNA Based Characterization
2. Stem Cell HLA Typing
3. Stem Cell Nucleic Acid Extraction and Purification, & Associated PCR/RT-PCRReagents

F. Isolation / Characterization Services

1. Stem Cell HLA Typing Services
2. Stem Cell Custom Services
3. Stem Cell Custom Antibodies

G. Stem Cell Culture Media & Reagents
H. Growth Factors & Cytokines
I. Stem Cell Gene Regulation
J. In vivo / In vitro Cell Tracking
K. Expansion / Differentiation Services
L. Stem Cell Lines

VI. Market Size

A. Definition of “Stem Cell Research Products”

B. Experimental Approach

C. Stem Cell Research Products, Market Size (in Millions)

D. Stem Cell Antibodies, Market Size (in Millions)

E. Stem Cell Therapies, Market Size (in Billions)

VII. Current Market Assessment

A. Breakdown of Research Segments by End-user Application

1. Basic Research
2. Applied Research

a. Autologous and Allogeneic Cell Therapy
b. Toxicology Screening for Drug Discovery and Development

B. Breakdown of Stem Cell Research by Cell Type

1. Cord Blood Stem Cells
2. Dental Stem Cells
3. iPSCs

C. Breakdown of Stem Cell Research by Species

D. Publication Rate Analysis

1. Overview of Stem Cell Publication Rates
2. Comparative Analysis of Stem Cell Publication Trends

E. Sources of Stem Cell Funding

1. Federal
2. State
3. Private

F. Patent Analysis

G. Geographical Analysis: Domestic vs. International Status

VIII. MARKET TRENDS: DETAILED END-USER SURVEY (SCIENTIST PANEL)

A. Survey Overview

B. Characterization of Market Survey Respondents

1. Geographic Distribution of Respondents
2. Respondent Breakdown by Industry Affiliation
3. Breakdown of Respondents by Duration of Stem Cell Activity

C. Survey Findings

1. Breakdown of Stem Cell Research Activity by Cell Type

2. Dominant Stem Cell Markers

3. Market Penetration of Stem Cell Markers by Cell Type

a. Human Embryonic Stem Cell (hESCs)
b. Mesenchymal Stem Cell (MSCs)
c. Neural Stem Cells (NSCs)
d. Hematopoietic Stem Cells (HSCs)

D. Preferred Providers of Stem Cell Antibodies

IX. MARKET FORECASTS

A. Near-term (1-3yrs): Stem Cells as Tools for Drug Discovery

B. Short-term (3-5yrs): Therapies Involving Cord Blood and Adult Stem Cells

C. Long-Term (10yrs): Therapies involving hESCs

X. STRATEGIES FOR ACCESSING THE MARKETPLACE

A. Top Research Institutions Performing Stem Cell Research

1. University of Wisconsin, including WARF, WiCell, and the WISC Bank
2. Johns Hopkins University
3. US National Institutes of Health (NIH)
4. California Institute for Regenerative Medicine

B. Events of Interest

XI. CONCLUSIONS

Market Report Overview: Stem Cell Research Products

Executive Summary: Stem Cell Research Products

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