Mesenchymal stem cells (MSCs) are multipotent stem cells that can differentiate into a variety of cell types, including osteoblasts, chondrocytes, myocytes, and adipocytes. MSCs are of intense therapeutic interest, because they represent a population of cells with the potential to treat a range of acute and degenerative diseases.
MSCs are advantageous over other stem cells types for a variety of reasons, including that they are immuno-privileged, making them an advantageous cell type for allogenic transplantation. Because of their unique capacity to form structural tissues, MSCs also being explored for use in 3D printing applications.
MSCs are of intense therapeutic interest, because they represent a population of cells that have the potential to treat a wide range of acute and degenerative diseases.
Key Dates in the Discovery of Mesenchymal Stem Cells (MSCs)
The discovery of mesenchymal stem cells (MSCs) dates back to the early 1900’s.
In 1924, the Russian-born researcher Alexander Maximow used histology to identify a type of precursor cell within the mesenchyme that could differentiate into a variety of blood cell types. While the term mesenchymal stem cell did not exist, this is the earliest known reference to the cell type.
Nearly 40 years later, in the 1960’s, researchers Ernest McCulloch and James Till identified the clonal qualities of marrow cells. , It then took another decade until an ex vivo assay was developed that allowed for examination of the clonal nature of multipotent marrow cells.
This assay was developed by Friedenstein’s team of researchers in the 1970’s, although the stromal cells of interest (now called mesenchymal stem cells) were referred as colony-forming unit-fibroblasts (CFU-f).
Although the first clinical trials of MSCs occurred in 1995, hundreds of clinical trials have since been initiated.
Interestingly, it took until the turn of the century (2000) for research supply companies to give enough credibility to the cell type to launch research tools that would support investigation of the cell type by the scientific community.
Later research and experimentation further characterized the plasticity of marrow cells and how their differentiation into mature cell types could be manipulated by environmental stimuli. For instance, growing marrow stromal cells in the presence of osteogenic stimuli, such as inorganic phosphate, ascorbic acid, dexamethasone, and related stimuli, can drive differentiation into osteoblasts (bone producing cells). Similarly, the presence of transforming growth factor-best (TGF-b) has the ability to induce chondrogenic (cartilaginous) traits.
To learn more, read the article “Benefits of Mesenchymal Stem Cells (MSC) Over Other Stem Cell Types.”
 Wan C, He Q, McCaigue M, Marsh D, Li G (2006). “Nonadherent cell population of human marrow culture is a complementary source of mesenchymal stem cells (MSCs)”.Journal of Orthopaedic Research 24 (1): 21–8.
 Becker AJ, McCULLOCH EA, Till JE (1963). “Cytological Demonstration of the Clonal Nature of Spleen Colonies Derived from Transplanted Mouse Marrow Cells”. Nature 197(4866): 452–4.
 Siminovitch L, Mcculloch EA, Till JE (1963). “The distribution of colony-forming cells among spleen colonies”. Journal of Cellular and Comparative Physiology 62 (3): 327–36.
 Friedenstein AJ, Deriglasova UF, Kulagina NN, Panasuk AF, Rudakowa SF, Luriá EA, Ruadkow IA (1974). “Precursors for fibroblasts in different populations of hematopoietic cells as detected by the in vitro colony assay method”. Experimental hematology 2 (2): 83–9.
 Friedenstein AJ, Gorskaja JF, Kulagina NN (1976). “Fibroblast precursors in normal and irradiated mouse hematopoietic organs”. Experimental hematology 4 (5): 267–74.
 Wang S et al. (2012). “Clinical applications of mesenchymal stem cells”. Jour of Hematology and Oncology (19).