A geometric evolution of cell based assay development for drug discovery.
StemTek Therapeutics, a leading Spanish biotech start up, announced the availability of Cell2Sphere, an innovative 3D cell culture kit created specifically for use in cancer stem cell research, pharmaceutical drug development and personalized medicine. Cell2Sphere frozen spheroid tissue culture samples increase the shelf life of today’s 3D cultures, enhancing the biological relevance of pre-clinical in vitro 3D culture efficacy assays.
Cell2Sphere is a scalable solution for High-throughput screening (HTS) and detection of phenotypic or genetic changes in cancer stem cells. By more closely resembling the natural environment of tumor cells, Cell2Sphere enriched 3D spheroids allow for more comprehensive, accurate, and reproducible data for in vitro to in vivo predictions in the search for therapeutic compounds and designer molecules to stop cancer.
“The Cell2Sphere 3D kit has allowed us to achieve results that wouldn’t have been possible with our on-site tissue culture program alone. We have saved weeks of hard work while also being able to focus on data mining large amounts of statistically sound data sets,” said Dr. Javier A. Menendez, co-founder and chairman of Metabostem, a biopharmaceutical company that develops breakthrough oncology drugs directed at the unique metabolic features of cancer stem cells (CSC). “We’ve been waiting for an innovative, easy-to-use CSC-based platform to let us focus on drug screening rather than on time-consuming technical issues. Without requiring additional skills, we can now easily design results-based testing, streamline budgeting and improve planning with this kit.”
Using a patented scaffold-free technology, Cell2Sphere tumor spheroid cells arrive frozen and grow in a standard 96 well ultra low-adhesion plate. Developed by molecular and cellular oncology specialists at Stemtek Therapeutics, Cell2Sphere is the result of rigorous analysis to push the boundaries in early stage drug screening to develop new anticancer therapies.
According to Angel Garcia Martin, CEO of StemTek Therapeutics, “Only about 10 percent of compounds progress successfully through clinical development. Many drugs fail 2 during clinical trials, especially during phase III, which is the most expensive phase of development, largely due to the lack of clinical efficacy or unacceptable toxicity. As researchers we understand that 3D spheroid tissue culture is more accurate but a notoriously time and labor intensive process, so we created a universal solution to solve this. Much like DNA kits have saved labs many hours in time intensive tasks, we believe 3D spheroid tissue culture will become mainstream allowing researchers to dedicate less time to growing tissue samples and spend more time better understanding cancer cell biology. So we can stop reinventing the wheel and focus on finding a cure.”
The Cell2Sphere product kit includes three elements:
(i) a standard 96 well plastic plate that can be directly used in existing drug screening platforms
(ii) Cancer Stem Cell enriched single cells in each well
(iii) a specific cell culture medium
Available now in the most common cancer cell lines, Cell2Sphere also offers custom made plates for drug development companies. In the near future, patient derived xenograft (PDX) material and cells from primary human tumors will be offered, allowing a personalized medicine approach. Samples are delivered frozen and last for several months for easy planning of experiments. StemTek offers ready-to-use cell cultures or customized made-to-order cultures. For pricing, orders and availability go here.
- Ready-to-use 3D cell based assay comes with tumor spheroids derived from cancer stem cells in TN Breast, pancreas, colon, brain, lung and ovarian cancer cell lines.
- Made-to-order 3D cell based assay can be developed for custom cell lines, PDX-derived and primary human tumor cells.
- More accurate screening, 3D spheroids offer researchers increased biological relevance by recreating human tumor cell biology
- Storable, samples are snap-frozen to -80 C and delivered packed in dry ice, ready for use or cold storage for up to 6 months.
- Scalable, save on development costs while improving predictability of compound efficacy of lead molecules in drug screening.
- For those seeking primary tumor cell lines for use in personalized cancer therapy, consult with StemTek for patient derived tumor cells
- Facilitates drug discovery process and speeds time to clinical trials while reducing false positives.
Founded in 2013, StemTek is a biotech startup entirely dedicated to cancer stem cell research and drug discovery. StemTek uses 3D cell based assay automated for HTS, 3 allowing the company to test thousands of compounds that target cancer stem cells to stop spheroid formation. 3D cell culture systems allow for stronger, more efficient and reliable drug screening. StemTek collaborates with pharmaceutical and biotech companies to accelerate early stage drug screening to develop new anticancer therapies. With over thirty years combined experience in molecular and cellular oncology, StemTek’s goal is to find treatments that put an end to relapse. Join our fight @StemTekTher or for more information go to: www.stemtektherapeutics.com
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