Mesenchymal stem cells (MSCs) are multipotent stem cells that can differentiate into a variety of cell types, including osteoblasts, chondrocytes, myocytes, and adipocytes. MSCs are of intense therapeutic interest, because they represent a population of cells with the potential to treat a range of acute and degenerative diseases.
MSCs are advantageous over other stem cells types for a variety of reasons, including that they are immuno-privileged, making them an advantageous cell type for allogenic transplantation. Because of their unique capacity to form structural tissues, MSCs also being explored for use in 3D printing applications.
MSCs are of intense therapeutic interest, because they represent a population of cells that have the potential to treat a wide range of acute and degenerative diseases.
Key Dates in the Discovery of Mesenchymal Stem Cells (MSCs)
The discovery of mesenchymal stem cells (MSCs) dates back to the early 1900’s.
In 1924, the Russian-born researcher Alexander Maximow used histology to identify a type of precursor cell within the mesenchyme that could differentiate into a variety of blood cell types. While the term mesenchymal stem cell did not exist, this is the earliest known reference to the cell type.
Nearly 40 years later, in the 1960’s, researchers Ernest McCulloch and James Till identified the clonal qualities of marrow cells. , It then took another decade until an ex vivo assay was developed that allowed for examination of the clonal nature of multipotent marrow cells. [Read more…]