Stem cells as therapeutics: will direct cell reprogramming make it possible?
Is regenerative medicine poised to lead a revolution in the treatment of disease, as it unfolds its power to rebuild damaged or diseased tissue?
There has been tremendous activity over the last decade in the development of stem cells for use as therapeutics. Today, there are over 5,000 “stem cell” trials registered on ClinicalTrials.gov and publications have increased dramatically in recent years, demonstrating the rapidly growing interest of the scientific community. However, for all its promise, stem cells are yet to deliver on this therapeutic potential, and this failure appears due to various technical challenges that still need to be overcome. [Read more…]